Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction

Background and objective: Five-membered heterocycle compounds having single oxygen nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole have a broad range of biological activities therapeutic value. In view strategic design antimicrobial compounds, several new ester-functionalized isoxazoles were synthesized characterized. Methods: A regioselective isoxazole incorporating an anthracene moiety was adducted via effective 1,3-dipolar cycloaddition between nitrile oxide propargyl bromide dipolarophile. Results: Synthesized 4 underwent nucleophilic substitution reaction to produce unprecedented 6a-j, by condensation with equimolar amounts different generated in situ sodium carboxylate upon dissolving acetonitrile refluxing. The chemical structure all target proved (FT-IR, 1H-NMR, APT13C-NMR) techniques their antibacterial antifungal evaluated. Conclusion: Allnewly synthesizedcompounds6 a-j been obtained good yields after purification column chromatography. They showed significant activity screening against two bacterial strains, Escherichia coli Staphylococcus aureus fungi strain, Candida albicans, using disc diffusion method.